XRCC4

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X-ray repair complementing defective repair in Chinese hamster cells 4
XRCC4

PDB ID : 1IK9
PDB1IK9 3MUD 3II6 1FU1
HGNCXRCC4
Gene CardXRCC4
Entrez7518
RefSeqNM_003401
UniProtQ13426
UCSCBrowser view
WikipediaXRCC4
Protein FamilyXRCC4, N-terminal domain
TypeDNA repair
Ensembl Exp.Human

Function

XRCC4 (X-ray cross complementation protein 4) works with DNA ligase IV (LIG4) and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining (NHEJ) and the completion of V(D)J recombination events. Normal development and tumor suppression require NHEJ. Alternative transcription initiation and alternative splicing generates several transcript variants.

ENCODE ChIP-seq Datasets

No Available Data

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

Select MotifCell Line:   Lab:   Protocol:   Treatment:   Antibody:  



Binding of Other Transcription Factors or Histone Marks at the XRCC4 Peaks

No Available Data

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