RAD21

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RAD21 homolog (S. pombe)
RAD21
PDBsearch RAD21
HGNC(alias)RAD21 (SCC1,KIAA0078,hHR21)
Gene CardRAD21
Entrez5885
RefSeqNM_006265
UniProtO60216
UCSCBrowser view
WikipediaRAD21
Protein FamilyWinged helix DNA-binding domain
TypeDNA repair
Ensembl Exp.Human

Function

RAD21 (a homolog of the Schizosaccharomyces pombe gene) is a nuclear phosphoprotein involved in the repair of DNA double-strand breaks that becomes hyperphosphorylated during mitosis. It is a component of the cohesin complex which forms a large proteinaceous ring within which sister chromatids are trapped. During mitosis, separase cleaves RAD21 from the complex, allowing sister chromatids to separate. RAD21 also is involved in apoptosis, via its cleavage by either caspase 3 or 7.

ENCODE ChIP-seq Datasets

Indicated in the matrix are the numbers of datasets specified by lab and cell line; when the number is greater than 1, multiple ChIP-seq experiments have been performed, some upon treatments. Click the numbers to download the data files on ChIP-seq peaks, alignments, etc.

+/-
HudsonAlpha
Stanford
Yale
GM12878 1 1
H1-hESC 1 1
HeLa-S3 1
HepG2 1 1
K562 1 1
SK-N-SH_RA 1


Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

Average histone modification profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks, separately for peaks that are proximal ([-1kb, +1kb]) to an annotated transcript (dashed lines) start sites and for peaks that are distal (more than 1kb) to all annotated transcripts (solid lines) start sites. Proximal profiles are arranged such that the transcriptional direction of the nearest transcript is toward the right. Histone modification data were generated by the Broad team, using antibodies to pull down modified histones followed by deep sequencing of the genomic DNA associated with the modified histones. Only histone modification data from the same cell line as the TF ChIP-seq data are shown.

Mouse over a curve to reveal its identity. Mouse over a histone modification in the legend to show its curves and gray out other histone modifications in the figures. Click a histone modification in the legend to toggle on/off its curve in all figures. Click the “Proximal” or “Distal” button in the legend to show only the average histone modification profiles anchored around ChIP-seq peaks that are proximal or distal to annotated transcripts.

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

Average nucleosome occupancy profiles are shown for the [-2 kb, +2 kb] window around the summits of TF ChIP-seq peaks, separately for peaks that are proximal to an annotated transcript (red lines) and for peaks that are distal to all annotated transcripts (blue lines), as defined in the previous section. Nucleosome positioning data in GM12878 and K562 were generated by the Stanford team, with micrococcal nuclease digestion of chromatin followed by deep sequencing of mononucleosomal DNA.