NR4A1

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nuclear receptor subfamily 4, group A, member 1
NR4A1

PDB ID : 2QW4
PDB2QW4
HGNC(alias)NR4A1 (N10,TR3,GFRP1,NUR77,NAK-1,HMR,NGFIB)
Gene CardNR4A1
Entrez3164
RefSeqNM_001202233
UniProtP22736
UCSCBrowser view
WikipediaNR4A1
Protein FamilyGlucocorticoid receptor-like (DNA-binding domain)
TypePol II TF
Ensembl Exp.Human

Function

NR4A1 (nuclear receptor subfamily 4, group A, member 1) is an orphan nuclear receptor, and a member of the steroid-thyroid hormone-retinoid receptor superfamily. It binds the NGFI-B response element 5'-AAAAGGTCA-3'. Expression of NR4A1 is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. It may act with NURR1 to co-regulate the expression of delayed-early genes during liver regeneration, and also may inhibit NF-kappa-B transactivation of IL2. Translocation of NR4A1 from the nucleus to mitochondria induces apoptosis.

ENCODE ChIP-seq Datasets

No Available Data

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

Select MotifCell Line:   Lab:   Protocol:   Treatment:   Antibody:  



Binding of Other Transcription Factors or Histone Marks at the NR4A1 Peaks

No Available Data

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