GCN5

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K(lysine) acetyltransferase 2A
GCN5

PDB ID : 1Z4R
PDB1Z4R 3D7C 1F68
HGNC(alias)KAT2A (GCN5,PCAF-b,GCN5L2)
Gene CardKAT2A
Entrez2648
RefSeqNM_021078
UniProtQ92830
UCSCBrowser view
WikipediaKAT2A
Protein FamilyAcyl-CoA N-acyltransferases (Nat)
Typehistone acetylation complexes
Ensembl Exp.n/a

Function

GCN5 (also known as KAT2A) is a histone acetyltransferase (HAT) that functions as a transcriptional activator. It also functions as a repressor of NF-kB by promoting ubiquitination of the NF-kB subunit RELA in a HAT-independent manner. GCN5 is a component of both the SAGA and ATAC complexes, which conduct HAT activity on histones H3 and H4. In HIV-1 infection, the viral protein TAT recruits GCN5, which in turn regulates TAT's transactivating activity and may help induce chromatin remodeling of proviral genes. PCAF (p300/CBP-associated factor, also known as KAT2B) is a paralog of GCN5 that associates with Myc, p53, and several other proteins.

ENCODE ChIP-seq Datasets

No Available Data

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

Select MotifCell Line:   Lab:   Protocol:   Treatment:   Antibody:  



Binding of Other Transcription Factors or Histone Marks at the GCN5 Peaks

Select HeatmapLab:   Cellline:  

  • Comparison with the GCN5 peaks in GM12878 cells generated by SYDH

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