ERalpha a

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estrogen receptor 1

PDB2FAI 2JFA 2OCF 2P15 2QAB 2QXM 3CBM 3HLV 1G50 1PCG 1XP6 1XP9 2IOG 2R6W 1ERR 1SJ0 1X7R 2AYR 2B23 2G5O 2IOK 2QXS 3CBO 3CBP 1ERE 1QKT 1XPC 1YIM 2BJ4 2G44 2OUZ 3L03 3OS9 1GWR 1XP1 1YIN 2B1Z 2Q70 2QA8 1A52 1GWQ 1HCP 1L2I 1QKU 1ZKY 2B1V 2POG 2Q6J 3DT3 3ERD 1AKF 1HCQ 1UOM 1XQC 2I0J 2QH6 2QSE 2QZO 3ERT 3HM1 3OS8 1R5K 1X7E 2JF9 2QA6 2QE4 2QGT 2QGW 2QR9 2R6Y 3OSA
HGNC(alias)ESR1 (NR3A1,ESR,Era)
Gene CardESR1
UCSCBrowser view
Protein FamilyGlucocorticoid receptor-like (DNA-binding domain)
TypePol II TF
Ensembl Exp.n/a


ER-α ((estrogen receptor α), also known as ESR1 (estrogen receptor 1) or NR3A1 (nuclear receptor subfamily 3, group A, member 1)) is a nuclear hormone receptor activated by estrogen ligand binding. It localizes to the nucleus where it forms a homodimer or a heterodimer with ERbeta (ESR2), followed by binding to the estrogen response element (ERE) in the promoter region of target genes. Steroid hormones such as ER-α are involved in the regulation of genes affecting cellular proliferation and differentiation in many different target tissues. Estrogen is responsible for the growth and maintenance of the skeleton and the normal functioning of the cardiovascular and nervous systems. Estrogen receptors also are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing of ER-α results in several transcript variants, which differ in their 5'-UTRs and use different promoters.

ENCODE ChIP-seq Datasets

Indicated in the matrix are the numbers of datasets specified by lab and cell line; when the number is greater than 1, multiple ChIP-seq experiments have been performed, some upon treatments. Click the numbers to download the data files on ChIP-seq peaks, alignments, etc.

ECC-1 3
T-47D 3

Average Profiles of Modified Histones around the Summit of ChIP-seq Peaks

No Available Data

Average Profiles of Nucleosomes around the Summit of ChIP-seq Peaks

No Available Data

Motifs Enriched in the Top 500 ChIP-seq Peaks

The sequences of the top 500 TF ChIP-seq peaks were used to identify enriched motifs de novo, using the MEME-ChIP suite of tools. Five motifs are reported (M1 to M5), with motif name, sequence logo, and number of peaks out of the top 500 peaks that contain a site for the motif. The motifs are then used to scan the entire set of ChIP-seq peaks and the two flanking (control) regions using the FIMO tool, and two quantities are reported for bins of peaks sorted by their ChIP-seq q-values: percentage of the peaks that contain a site for the motif, and the distribution of the distances of the motif site to the summit of the peak.

Select MotifCell Line:   Lab:   Protocol:   Treatment:   Antibody:  

Cell Line:ECC-1   Lab:HudsonAlpha   Protocol:v041610.2   Treatment:Genistein_100nM   Antibody:ERalpha_a   

Binding of Other Transcription Factors or Histone Marks at the ERalpha a Peaks

No Available Data

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